Integration of metabolism, energetics, and signal transduction :
[Book]
unifying foundations in cell growth and death, cancer, atherosclerosis, and Alzheimer disease /
Robert K. Ockner
xvii, 387 pages :
color illustrations ;
26 cm
Includes bibliographical references and index
pt. I. Prologue. Disparate themes: origins and integration -- pt. II. Fatty acids, mitochondria, and signal transduction: integrated control of cell proliferation, injury, and death. Introduction to Part II -- Nutrient and energy metabolism in cell proliferation -- Fatty acids and growth regulation -- Mitochondrial function in cell growth and death -- Metabolic effects of antiproliferative agents -- Fatty acids and mitochondria, cell growth and injury: broader implications -- Metabolism and gene expression in liver regeneration -- Part II conclusions -- pt. III. Fatty acids, ketone bodies, and brain metabolism: implications for neuronal function and Alzheimer disease. Introduction to Part III -- Energetics of neuronal activation -- Utilization of oxidizable substrates in brain -- Astrocyte metabolism and astrocyte-neuron interaction -- Neuronal energy metabolism in brain: astrocyte as metabolic "buffer" and mediator of neuronal injury -- Pathogenesis of Alzheimer disease: metabolic factors -- Part III conclusions -- pt. IV. Epilogue. Looking back, looking ahead