عنوان

Human cholinesterases and anticholinesterases /

0126552908 (hardcover)

dltt

Human cholinesterases and anticholinesterases /

[Book]

Hermona Soreq, Haim Zakut

San Diego :

Academic Press,

c1993

xiv, 314 p. :

ill. ;

24 cm

Includes bibliographical references (p. 247-301) and index

(cont) Manipulations of butyrylcholinesterase gene expression modulate murine megakaryocytopoiesis in vitro -- In vivo amplification of the human cholinesterase genes -- Scientific and environmental implications -- Human acetylcholinesterase and butyrylcholinesterase genes: comparative analysis -- Expression of recombinant acetylcholinesterase and butyrylcholinesterase in microinjected xenopus oocytes -- Unusual tumor butyrylcholinesterase mRNA transcripts -- In ovo expression of human butyrylcholinesterase muteins reveals structure-function relationships -- Isolation of mutated butyrylcholinesterase sequences from cDNA libraries and their detection in genomic DNA -- Putative involvement of cholinesterases in development -- Modifications in the human cholinesterase genes -- Pollution and ecological implications

Biochemical and biological background -- Overview of cholinesterases -- Biochemically defined subsites and their roles in hydrolysis activity -- Anticholinesterases -- Cell type and subcellular localization of cholinesterases -- Molecular polymorphism and its genomic origin -- Putative biological roles of cholinesterases -- Evolutionary divergence and conservation of cholinesterases -- Genetic variants of human cholinesterases -- Cholinesterases and disease states -- Human cholinesterase genes and their expression -- Molecular cloning and expression of human cholinesterase coding sequences -- Promoter elements and alternative splicing in the human acetylcholinesterase gene -- Search for molecular origins of butyrylcholinesterase polymorphism by cDNA screening, deletion mutagenesis, and xenopus oocyte co-injection -- Chromosomal localization of human cholinesterase genes -- Genomic origin of butyrylcholinesterase variants: multiple point mutations in the butyrylcholinesterase -- Structure-function relationships in human butyrylcholinesterase variants

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Cellular signal transduction

Cholinergic mechanisms

Cholinesterase genes

Cholinesterase inhibitors

Cholinesterases

Cholinesterase Inhibitors-- metabolism

Cholinesterases-- physiology

X380

Soreq, H

Zakut, Haim,1935-

19931011094050.0

[Book]

Y