Clostridial toxins and the central nervous system: studies on in situ tissues -- Clostridial neurotoxins and the central nervous system: functional studies on isolated preparations -- Pharmacological antagonism of clostridial toxins -- Part III. Immunology and Assays: Antibodies against botulinum neurotoxin -- Assays for botulinum and tetanus toxins -- Part IV. Clinical Issues: Animal models of botulism and tetanus -- Botulism -- Clinical aspects of tetanus -- Clostridial toxins as therapeutic agents
Part I. Origin and Structure: Bacterial sources of clostridial neurotoxins -- Bacteriophages and plasmids in clostridium botulinum and clostridium tetani and their relationship to production of toxins -- The structure of botulinum neurotoxin -- The structure of tetanus toxin -- Part II. Pharmacology and Toxicology: Cell surface receptors for protein toxins -- Entry of bacterial toxins into mammalian cells -- Peripheral actions of the botulinum toxins -- Peripheral actions of tetanus toxin -- Axoplasmic transport and transynaptic movement of tetanus toxin