Historical perspective on von Willebrand disease / Erik Berntorp and Margareta Blombäck -- Biosynthesis and organization of von Willebrand factor / Sandra L. Haberichter -- Von Willebrand factor structure and function / Robert R. Montgomery and Sandra L. Haberichter -- Modulation of von Willebrand factor by ADAMTS13 / Jennifer Barr and David Motto -- Animal models in von Willebrand disease / Cécile V. Denis, Olivier D. Christophe, and Peter J Lenting -- Classification of von Willebrand disease / Javier Batlle, Almudena Pérez-Rodríguez and María Fernanda López-Fernández -- The epidemiology of von Willebrand disease / Giancarlo Castaman and Francesco Rodeghiero -- Clinical aspects of von Willebrand disease : bleeding history / Paula D. James and Alberto Tosetto -- Laboratory diagnosis of von Willebrand disease : the phenotype / Ulrich Budde and Emmanuel J Favaloro -- Molecular diagnosis of von Willebrand disease : the genotype / Anne C Goodeve and Reinhard Schneppenheim -- Clinical, laboratory, and molecular markers of type 1 von Willebrand disease / David Lillicrap, Francesco Rodeghiero, and Ian Peake -- Clinical, laboratory, and molecular markers of von Willebrand disease type 2 / Dominique Meyer, Edith Fressinaud and Claudine Mazurier -- Clinical, laboratory and molecular markers of von Willebrand disease type 3 / Luciano Baronciani, Augusto B. Federici and Jeroen C.J. Eikenboom -- Pediatric aspects of von Willebrand disease / Jorge Di Paola and Thomas Abshire -- Women with von Willebrand disease / Christine A. Lee, Rezan A. Kadir, and Peter A. Kouides -- The use of desmopressin in von Willebrand disease / Stefan Lethagen, Augusto B. Federici, and Giancarlo Castaman -- The use of plasma-derived concentrates / Pier Mannuccio Mannucci, Massimo Franchini -- Prophylaxis in von Willebrand disease / Erik Berntorp -- Pathophysiology, epidemiology, diagnosis, and treatment of the acquired von Willebrand syndrome / Ulrich Budde, Augusto B. Federici, and Jacob H. Rand -- Gene therapy for von Willebrand disease / Marinee K.L. Chuah, Inge Petrus, and Thierry VandenDriessche