عنوان

Peptidomimetics in organic and medicinal chemistry /

111868303X (electronic bk.)

1118683846 (electronic bk.)

9781118683033 (electronic bk.)

9781118683842 (electronic bk.)

1118683145

9781118683149

9781119950608 (hardback)

dltt

Peptidomimetics in organic and medicinal chemistry /

[Book]

Dr. Andrea Trabocchi and Professor Antonio Guarna

1404

1 online resource

Includes bibliographical references and index

"A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands.Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, and scaffolds for combinatorial chemistry of peptidomimetics. Case studies in the hit-to-lead process, such as the development of integrin ligands and thrombin inhibitors, illustrate the successful application of peptidomimetics in drug discovery"--

"Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature"--

Peptidomimetics in organic and medicinal chemistry

9781119950608

Drugs-- Design.

Peptide drugs.

Proteins-- Therapeutic use.

MED-- 071000

Trabocchi, Andrea

Guarna, Antonio

Ohio Library and Information Network.

20140415154310.0

rda

[Book]

Y