عنوان

A handbook for DNA-encoded chemistry :

1118832671 (epub)

1118832698 (electronic bk.)

1118832736 (electronic bk.)

9781118832677 (epub)

9781118832691 (electronic bk.)

9781118832738 (electronic bk.)

1118832639 ( mobi)

9781118487686 (cloth)

9781118832639 ( mobi)

dltt

A handbook for DNA-encoded chemistry :

[Book]

theory and applications for exploring chemical space and drug discovery /

edited by Robert A. Goodnow, Jr

1 online resource (xxv, 453 pages, 16 unnumbered pages of plates) :

illustrations

Includes bibliographical references and index

Just enough knowledge? -- A brief history of the development of combinatorial chemistry and the emerging need for DNA-encoded chemistry -- A history of DNA-encoding -- DNA-compatible chemistry -- Foundations of a DNA-encoded library (DEL) -- Practices for synthesizing DNA-encoded libraries -- Chemical gene design for DNA-encoded libraries -- Analytical challenges for DNA-encoded library systems -- Information technology: functionality and architectures for DNA-encoding -- Theoretical considerations of the application of DNA-encoded libraries to drug discovery -- Begin with the end in mind : the hit-to-lead process -- Enumeration and visualization of large combinatorial chemical libraries -- Screening large compound collections -- Reported applications of DNA-encoded library chemistry -- Dual-pharmacophore DNA-encoded chemical libraries -- Hit identification and hit follow-up -- Using DNA to program chemical synthesis, discover new reactions, and detect ligand binding -- An outlook and the changing feasibility and economics of chemical diversity exploration with DNA-encoded combinatorial approaches -- Keeping the promise? an outlook on dna chemical library technology

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This book comprehensively describes the development and practice of DNA-encoded library synthesis technology. Together, the chapters detail an approach to drug discovery that offers an attractive addition to the portfolio of existing hit generation technologies such as high-throughput screening, structure-based drug discovery and fragment-based screening. The book: Provides a valuable guide for understanding and applying DNA-encoded combinatorial chemistry Helps chemists generate and screen novel chemical libraries of large size and quality Bridges interdisciplinary areas of DNA-encoded combi

Handbook for DNA-encoded chemistry

9781118487686

Combinatorial chemistry-- Technique.

DNA-- Synthesis.

Combinatorial Chemistry Techniques-- methods.

DNA-- chemical synthesis.

Drug Discovery-- methods.

Gene Library.

Small Molecule Libraries-- chemical synthesis.

MED-- 071000

Goodnow, Robert A.,Jr.

Ohio Library and Information Network.

20140611152244.0

rda

[Book]

Y