Overview of cancer biology -- The burden of cancer -- Nature and nurture in oncogenesis -- DNA replication and the cell cycle -- Growth signaling pathways and the new era of targeted treatment of cancer -- Oncogenes -- Tumor suppressors -- Cell death -- Senescence, telomeres, and cancer stem cells -- Genetic instability, chromosomes, and repair -- There is more to cancer than genetics: regulation of gene and protein expression by epigenetic factors, small regulatory RNAs, and protein stability -- Cell adhesion in cancer -- Tumor immunity and immunotherapy -- Tumor angiogenesis -- Cancer chemistry: designing new drugs for cancer treatment -- Biologically targeted agents from bench to bedside -- The diagnosis of cancer -- Treatment of cancer: chemotherapy and radiotherapy -- Caring for the cancer patient -- Systems biology of cancer