عنوان

The liver :

0470723130

9780470723135

dltt

The liver :

[Book]

biology and pathobiology /

editor, Irwin M. Arias ; associate editors, Harvey J. Alter ... [et al.]

5th ed

Hoboken, NJ :

Wiley-Blackwell,

2009

xxii, 1191 p., [24] p. of plates :

ill. (some col.) ;

29 cm

Includes bibliographical references and index

Gene regulation and in vivo function of liver transcription factors -- Liver repopulation by cell transplantation and the role of stem cells -- Hepatic encephalopathy -- The kidney in liver disease -- Critical role of the liver in coagulation -- Inheritable cholestatic disorders -- Alpha 1-antitrypsin deficiency -- Adaptive regulation of hepatocyte transporters in cholestasis -- Pathogenesis of portal hypertension -- Non-alcoholic fatty liver disease: a pathophysiological perspective -- Pathophysiology of alcoholic liver disease -- Inflammation and drug-induced liver injury -- Hepatocyte apoptosis -- Back to the future: a backward glance at the forward progress of hepatitis virus research -- Molecular biology of hepatitis viruses -- Immune mechanisms of viral clearance and disease pathogenesis during viral hepatitis -- Innate immune sensing and the toll-like receptors -- Clinical implications of the molecular biology of hepatitis B virus -- Viral escape mechanisms in hepatitis C and the clinical consequences of persistent infection -- Current and future therapy for hepatitis B and C -- Biological principles and clinical issues underlying liver transplantation for virus-induced end-stage liver disease -- Tissue engineering of the liver -- Aging and the uncertain roles of sirtuins -- The liver proteome -- Liver-directed gene therapy -- Novel strategies for manipulating hepatic gene expression in vivo -- Decoding the liver cancer genome -- Genome-wide expression profiling of human hepatocellular carcinoma -- Cell cycle control in the liver -- miRNAs and liver biology -- Imaging cellular proteins and structures: smaller, brighter, and faster -- Zebrafish as a model system for the study of liver development and disease -- The hepatocyte and the cancer cell: Dr Jekyll and Mr Hyde -- The role of endocannabinoids and their receptors in the control of hepatic functions -- Telomeres and aging, cancer, and hepatic fibrosis -- Treatment of cirrhosis with vitamin A-coupled liposomes carrying siRNA against heat shock protein 47 -- The "Green Liver" and transcriptional regulation of phase II detoxification genes

Organizational principles of the liver -- Embryonic development of the liver -- Microtubules, actin filaments and motor-mediated vesicular transport -- Molecular motors -- Ion pumps and molecular motors: P-, F-, and V-type ATPases -- Hepatocyte surface polarity: its dynamic maintenance and establishment -- Endocytosis as an essential process in liver function and pathology -- Membrane transport in hepatocellular secretion -- Mitochondria -- Nuclear pore complex -- Protein maturation and processing at the endoplasmic reticulum -- Protein degradation and the lysosomal system -- Peroxisome assembly, degradation, and disease -- Gap and tight junctions in liver: composition, regulation, and function -- Copper metabolism and the liver -- The central role of the liver in iron storage and regulation of systemic iron homeostasis -- Disorders of bilirubin metabolism -- The porphyrias -- Hepatic fatty acid metabolism and dysfunction -- Lipoprotein metabolism and cholesterol balance -- Bile acids and the enterohepatic circulation -- Hepatocyte basolateral membrane organic anion transporters -- Nuclear receptors regulate bile acid synthesis -- Hormonal regulation of bile secretion -- Nucleotide transport and regulation of bile formation -- The function of the canalicular membrane in bile formation and secretion -- Apical recycling of canalicular ABC transporters -- Cholangiocyte functions in health and disease: the ciliary connection -- The hepatic sinusoidal endothelial cell: morphology, function, and pathobiology -- Endothelial and pit cells -- Fenestrations in the liver sinusoidal endothelial cell -- Hepatic stellate cells -- Hepatic fibrosis -- Matrix -- Insulin resistance -- Ca²⁺ signaling in the liver -- Synthesis of and signalling through D-3 phosphoinositides -- Nitric oxide in the liver -- Role of intracellular iron movement and oxidant stress in hepatocellular injury -- Hypoxic, ischemic and reperfusion injury to liver -- Protective mechanisms against reactive oxygen species -- Regulatory pathways of liver gene expression: the central role of cyclic AMP -- AMPK: central regulator of glucose and lipid metabolism -- Energy metabolism -- Liver regeneration -- Interleukin-6 signaling during the acute-phase response of the liver -- Hepatocyte growth factor: its role in hepatic growth and pathobiology -- Ribosome biogenesis and its role in cell growth and proliferation in the liver --

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Liver-- Pathophysiology

Liver-- Physiology

Liver-- pathology

Liver-- physiology

Alter, Harvey J

Arias, Irwin M

20100416033133.0

[Book]

Y