Epidemiology of renal cell carcinoma / Xifeng Wu, Xiang Shu, Wong-Ho Chow, and Jian Gu -- Pathology of renal cell carcinoma / Priya Rao and Pheroze Tamboli -- Biology of renal cell carcinoma / Thai H. Ho, Ruhee Dere, and Cheryl L. Walker -- Inherited renal cell cancers / Eric Jonasch and Sarathi Kalra -- Interventional radiology procedures in renal cell carcinoma / Sharjeel H. Sabir and Alda L. Tam -- Management of small renal masses and early-stage renal cell carcinoma / Surena F. Matin -- Staging and surgical management of locally advanced renal cell carcinoma and the role of adjuvant and neoadjuvant therapy / Dae Y. Kim, Jose A. Karam, and Christopher G. Wood -- Integration of targeted therapy with cytoreductive nephrectomy and metastasectomy in the management of metastatic renal cell carcinoma / Bishoy A. Gayed, Jose A. Karam, Vitaly Margulis, and Christopher G. Wood -- Immunotherapeutic approaches for metastatic conventional-type renal cell carcinoma / Anasuya Gunturi and David F. McDermott -- Targeted therapies for metastatic conventional-type renal cell carcinoma / Tim Eisen and Ferdinandos Skoulidis -- Systemic therapies for metastatic renal cell carcinoma of variant histology -- Sumanta K. Pal and Toni K. Choueiri -- Prognostic and predictive biomarkers in renal cell carcinoma / David D. Chism and W. Kimryn Rathmell -- Management of complications of targeted therapies for metastatic renal cell carcinoma / Bradley Atkinson and Diana Cauley -- The role of traditional and stereotactic radiation in metastatic renal cell carcinoma / Amol J. Ghia and Seungtaek Choi -- Supportive care in advanced renal cell carcinoma / Sriram Yennurajalingam -- Integrative medicine in the management of renal cell carcinoma / Alejandro Chaoul, Gabriel Lopez, Richard Lee, M. Kay Garcia, Lorenzo Cohen -- Emerging therapies and future directions in renal cell carcinoma / George K. Philips and Michael B. Atkins