عنوان

Apoptosis, senescence and cancer /

1588295273 (hbk.)

9781588295279 (hbk.)

b431763

Apoptosis, senescence and cancer /

[Book]

edited by David A. Gewirtz, Shawn E. Holt, Steven Grant

2nd ed

Totowa, N.J. :

Humana Press,

2007

xvii, 599 p. :

ill. ;

26 cm

Cancer drug discovery and development

Includes bibliographical references and index

The intrinsic pathway of apoptosis. -- The extrinsic pathway of apoptosis. -- Evaluating the importance of apoptosis and other determinants of cell death and survival. -- Mitotic catastrophe. -- Autophagy and autophagic cell death. -- Regulation and function of detachment-induced cell death (anoikis) in cancer progression and metastasis. -- Structure and function of the telomere. -- Overview of senescence. -- Contributions of telomerase to tumorigenesis. -- The role of telomeres in genomic instability. -- Overview of the DNA damage checkpoint: ATM and ATR. -- Interactions between myc- and cyclin-dependent kinase inhibitors in cancer. -- Interplay between [gamma]H2AX and 53BP1 pathways in DNA double-strand break repair response. -- DNA-dependent protein kinase in repair, apoptosis, telomere maintenance, and chemotherapy. -- Resistance/signaling pathways. -- Ceramide and multidrug resistance. -- Chemo- and radiosensitization through inhibition of PI3K/Akt signaling. -- The advancement of epidermal growth factor receptor inhibitors in cancer therapy. -- Antimetabolites. -- Topoisomerase I poisons and apoptotic topoisomerase I-DNA complexes. -- Perturbations of cellular functions by topoisomerase II inhibitors: all roads lead to cell death? -- The significance of poly-targeting in apoptosis induction by alkylating agents and platinum drugs. -- Contributions of apoptosis and senescence to cytotoxicity produced by microtubule-stabilizing agents. -- Tyrosine kinase inhibitors. -- Monoclonal antibodies in lymphomas. -- Role of apoptosis in anti-angiogenic cancer therapies. -- Photodynamic therapy-induced apoptosis. -- Modulation of TRAIL signaling for cancer therapy

0

Apoptosis

Cancer cells-- Growth-- Regulation

Cancer-- Chemotherapy

Cancer-- Radiotherapy

Apoptosis

Cell Aging

Neoplasms-- drug therapy

Neoplasms-- radiotherapy

Gewirtz, David A

Grant, Steven

Holt, Shawn E

20080305104822.0

[Book]

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