عنوان

Analysis of aggregates and particles in protein pharmaceuticals /

0470497181 (cloth)

9780470497180 (cloth)

b427159

Analysis of aggregates and particles in protein pharmaceuticals /

[Book]

edited by Hanns-Christian Mahler, Wim Jiskoot

Hoboken, N.J. :

Wiley,

c2012

xvi, 443 p., [12] p. of plates :

ill. (some col.) ;

25 cm

Includes bibliographical references and index

The critical need for robust assays for quantitation and characterization of aggregates of therapeutic proteins -- Separation-based analytical methods for measuring protein aggregation -- Laser light scattering-based techniques used for the characterization of protein therapeutics -- Online detection methods and emerging techniques for soluble aggregates in protein pharmaceuticals -- Analytical methods to measure subvisible particulates -- Detection of visible particles in parenteral products -- Characterization of aggregates and particles using emerging techniques -- Ultraviolet absorption spectroscopy -- Fluorescence spectroscopy to characterize protein aggregates and particles -- Infrared spectroscopy to characterize protein aggregates -- Raman microscopy for characterization of particles -- Microscopic methods for particle characterization in protein pharmaceuticals -- Comparison of methods for soluble aggregate detection and size characterization -- Protein purification and its relation to protein aggregation and particles -- Formulation development and its relation to protein aggregation and particles

0

Pharmaceutical chemistry

Protein drugs-- Analysis

Chemistry Techniques, Analytical-- methods

Pharmaceutical Preparations-- analysis

Proteins-- pharmacokinetics

Jiskoot, Wim

Mahler, Hanns-Christian

20120622113137.0

[Book]

Y