عنوان

Principles of virology /

1555819338 (v. 1 pbk.)

1555819346 (v. 2 pbk.)

1555819516 (set pbk.)

1555819524 (set ebook)

9781555819330 (v. 1 pbk.)

9781555819347 (v. 2 pbk.)

9781555819514 (set pbk.)

9781555819521 (set ebook)

b419935

Principles of virology /

[Book]

Jane Flint, Department of Molecular Biology, Princeton University, Princeton, New Jersey; Vincent R. Racaniello, Department of Microbiology, College of Physicians and Surgeons, Columbia University, New York, New York; Glenn F. Rall, Fox Chase Cancer Center, Philadelphia, Pennsylvania; Anna Marie Skalka, Fox Chase Cancer Center, Philadelphia, Pennsylvania; with Lynn W. Enquist, Department of Molecular Biology, Princeton University, Princeton, New Jersey

4th edition

volumes :

color illustrations ;

28 cm

Revision of: Principles of virology / S.J. Flint ... [et al.]. 3rd ed

Includes bibliographical references and index

Volume 1. Molecular biology: Part 1: The Science of Virology: 1. Foundations: Luria's Credo - Why we study viruses - Virus prehistory - Discovery of viruses - The definitive properties of viruses - Viruses defined - Cataloging animal viruses - A common strategy for viral propagation - Perspectives - References -- 2. The infectious cycle: Introduction - The infectious cycle - The cell - The architecture of cell surfaces - Entering cells - Making viral RNA - Making viral proteins - Making viral genomes - Forming progeny virus particles - Viral pathogenesis - Overcoming host defenses - Cultivation of viruses - Assay of viruses - Viral reproduction: the burst concept - The one-step growth cycle - Systems biology - Perspectives - References -- Part II: Molecular Biology: 3. Genomes and Genetics: Introduction - Genome principles and the Baltimore System - Structure and complexity of viral genomes - What do viral genomes look like? - Coding strategies - What can viral sequences tell us? - The origin of viral genomes - The "big and small" of viral genomes: does size matter? - Genetic analysis of viruses - Perspectives - References -- 4. Structure: Introduction - Building a protective coat - Packaging the nucleic acid genome - Viruses with envelopes - Large viruses with multiple structural elements - Other components of virions - Perspectives - References -- 5. Attachment and Entry: Introduction - Attachment of virus particles to cells - Entry into cells - Import of viral genomes into the nucleus - Perspectives - References -- 6.Synthesis of RNA from RNA Templates: Introduction - The nature of the RNA template - The RNA synthesis machinery - Mechanisms of RNA synthesis - Paradigms for viral RNA synthesis - Cellular sites of viral RNA synthesis - Origins of diversity in RNA virus genomes - Perspectives - References -- 7. Reverse Transcription and Integration: Retroviral reverse transcription - Retroviral DNA integration is a unique process - Hepadnaviral reverse transcription - Perspectives - References -- 8. Synthesis of RNA from DNA Templates: Introduction - Transcription by RNA polymerase II - The cellular machinery alone can transcribe viral DNA templates - Viral proteins that govern transcription of viral DNA templates - Transcription of viral genes by RNA polymerase III - Inhibition of the cellular transcriptional machinery - Unusual functions of cellular transcription components - A viral DNA-dependent RNA polymerase - Perspectives - References -- 9. Replication of DNA Genomes: Introduction - DNA synthesis by the cellular replication machinery - Mechanisms of viral DNA synthesis - Exponential accumulation of viral genomes - Limited replication of viral DNA genomes - Limited replication of viral DNA genomes - Origins of genetic diversity in DNA viruses - Perspectives - References -- 10. Processing of Viral pre-mRNA: Introduction - Covalent modification during viral pre-mRNA processing - Export of RNAs from the nucleus - Posttranscriptional regulation of viral or cellular gene expression by viral proteins - Regulation of turnover of viral and cellular mRNAs in the cytoplasm - Production and function of small RNAs that inhibit gene expression - Perspectives - References -- 11. Protein Synthesis: Introduction - Mechanisms of eukaryotic protein synthesis - The diversity of viral translation strategies - Regulation of translation during viral infection - Perspectives - References -- 12. Intracellular Trafficking: Introduction - Assembly within the nucleus - Assembly at the plasma membrane - Interactions with internal cellular membranes - Transport of viral genomes to assembly sites - Perspectives - References -- 13. Assembly, Exit, and Maturation: Introduction - Methods of studying virus assembly and egress - Assembly of protein shells - Selective packaging of the viral genome and other components of virus particles - Acquisition of an envelope - Release of virus particles - Maturation of progeny virus particles - Cell-to-cell spread - Perspectives - References -- 14. The Infected Cell: Introduction - Signal transduction - Gene expression - Metabolism - Remodeling of cellular organelles - Perspectives - References -- Appendix: Structure, genome organization, and infectious cycles

Volume 2. Pathogenesis and control: 1. Infections of populations: History and Epidemiology: Introduction to viral pathogenesis - A brief history of viral pathogenesis - Viral epidemics in history - Epidemiology - Parameters that govern the ability of a virus to infect a population - Perspectives - References -- 2. Barriers to Infection: Introduction - An overview of infection and immunity - Successful infections must modulate or bypass host defenses - Viral tropism - Spread throughout the host - Organ invasion - Shedding of virus particles - Perspectives - References -- 3. The Early Host Response: Cell-autonomous and Innate Immunity: Introduction - The first critical moments of infection: how do individual cells detect a virus infection? - Intrinsic responses to infection - Soluble immune mediators of the innate immune response - The innate immune response - Perspectives - References -- 4. Adaptive Immunity and the Establishment of Memory: Introduction - Attributes of the host response - Lymphocyte development, diversity, and activation - Events at the site of infection set the stage for the adaptive response - Antigen processing and presentation - The cell-mediated response - The humoral (antibody) response - Immunological memory - Perspectives - References -- 5. Mechanisms of Pathogenesis: Introduction - Animal models of human diseases - Patterns of infection - Viral virulence - Pathogenesis - Perspectives - References -- 6. Cellular Transformation and Oncogenesis: Introduction - Oncogenic viruses - Activation of cellular signal transduction pathways by viral transforming proteins - Disruption of cell cycle control pathways by viral transforming proteins - Transformed cells must grow and survive - Tumorigenesis requires additional changes in the properties of transformed cells - Other mechanisms of transformation and oncogenesis by human tumor viruses - Perspectives - References -- 7. Human Immunodeficiency Virus Pathogenesis: Introduction - HIV is a lentivirus - Cellular targets - Routes of transmission - The course of infection - Origins of cellular immune dysfunction - Immune responses to HIV - Dynamics of HIV-1 reproduction in AIDS patients - Effects of HIV on different tissues and organ systems - HIV and cancer - Prospects for treatment and prevention - Perspectives - References -- 8. Vaccines: Introduction - The origins of vaccination - Vaccine basics - The science and art of making vaccines - Vaccine technology: delivery and improving antigenicity - The quest for an AIDS vaccine - Perspectives - References -- 9. Antiviral Drugs: Introduction - Discovering antiviral compounds - Examples of some antiviral drugs - Expanding target options for antiviral drug development - Two success stories: human immunodeficiency and hepatitis C viruses - Drug resistance - Perspectives - References -- 10. Evolution: Virus evolution - Classic theory of host-parasite interactons - How do virus populations evolve? - The origin of viruses - Host-virus relationships drive evolution - Lessons from paleovirology - Perspectives - References -- 11. Emergence: The spectrum of host-virus interactions - Encountering new hosts: ecological parameters - Expanding virual niches: some well-documented examples - Notable zoonoses - Host range can be expanded by mutation, recombination, or reassortment - New technologies uncover hitherto unrecognized viruses - A revolution in virus discovery - Perceptions and possibilities - What next? - Perspectives - References -- 12. Unusual Infectious agents: Introduction - Viroids - Satellites - Prions and transmissible spongiform encephalopathies - Perspectives - Refeences -- Appendix: Diseases, epidemiology, and disease mechanisms of selected animal viruses discussed in this book

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"Principles of Virology is the leading virology textbook because it does more than collect and present facts about individual viruses. Instead, it facilitates an understanding of basic virology by examining the shared processes and capabilities of viruses. Using a set of representative viruses to present the complexity and diversity of a myriad of viruses, this rational approach enables students to understand how reproduction is accomplished by known viruses and provides the tools for future encounters with new or understudied viruses. This fully updated edition represents the rapidly changing field of virology. A major new feature is the inclusion of 26 video interviews with leading scientists who have made significant contributions to the field of virology."-- c Provided by publisher.

Virology

Flint, S. Jane

Enquist, L. W., (Lynn W.)

Racaniello, V. R., (Vincent R.)

Rall, Glenn F.

Skalka, Anna M.

20151103161924.0

rda

[Book]

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