Recent Progress in the Chemical Synthesis of Antibiotics
[Book]
edited by G. Lukacs, M. Ohno.
Berlin, Heidelberg :
Springer Berlin Heidelberg,
1990.
CONTENTS: K. Tatsuta: Total Synthesis of Macrolide Antibiotics -- H. Kirst: Structural Modification of Macrolide Antibiotics -- T. Blizzard, M. Fisher, H. Mrozik, T. Shih: Avermectins and Milbemycins -- M. Isobe: Ansamacrolides -- J.-M. Beau: Polyene Macrolides: Stereostructural Elucidation and Synthetic Studies of a Few Members -- J.-M. Paris, J.-C. Barrière, C. Smith, P.-E. Bost: The Chemistry of Pristinamycins -- D. Bouzard: Recent Advances in the Chemistry of Quinolones -- B. Fraser-Reid, J.C. Lopez: Actinobolin and Bactobolin: Chemical Aspects and Syntheses -- F. De las Heras, M.-J. Camarasa, J.-M. Fiandor: Nucleosides: Potential Drugs for AIDS Therapy -- A. Golebiowski, J. Jurczak: Total Synthesis of Lincomycin and Related Chemistry -- M. Ohno, M. Otsuka: Synthetic Study on Man-Made Bleomycins Based on the Anticancer Mechanism of Natural Bleomycins -- W.A. Remers, B. Iyengar: Synthesis of Mitomycins -- O. Yonemitsu, K. Horita: Total Synthesis of Polyether Antibiotics -- G.J. Thomas: Synthesis of Anthracyclines Related to Daunomycin.-A.V. Rama Rao: Synthesis of Polynuclear Aromatic Antibiotics -- R.C. Thomas: Synthetic Aspects of Monocyclic -Lactam Antibiotics -- C. Palomo: Recent Advances in the Synthesis of PS-5 and PS-6 Antibiotics and Related Carbapenem Compounds -- E. Perrone, G. Franceschi: Synthesis of Penems -- M. Narisada, T. Tsuji: l-Oxacephem Antibiotics -- J. Marchand-Brynaert, L. Ghosez: Non -Lactam Analogs of Penicillins and Cephalosporins -- subject Index.
0
Twenty leading research groups from academic and industrial pharmaceutic laboratories have contributed to this unique compilation on the chemical synthesis of various classes of antibiotics. Anthracycline, bleomycin, ß-lactame, macrolide, polyether and the - of importance for cancer and AIDS treatment - nucleoside antibiotics are described by the contributors. The book will be a valuable reading for scientists and researchers involved in the development of new substances and drugs with antibiotic activity.