عنوان
پدید آورنده
موضوع
رده
کتابخانه
محل استقرار
95914P
انگلیسی
ST8 micellar/niosomal vesicular nanoformulation for delivery of naproxen in cancer cells: Physicochemical characterization and cytotoxicity evaluation
[Dissertation]
shahin shirvani
شاهین شیروانی
Tehran University of Medical Sciences, Medicine school
2018
Specialty
Infectious children
2018/08/07
Naproxen (NPX) is a non-steroidal anti-inflammatory drug (NSAID) used against avariety of diseases, includ-ing autoimmune disorders and chronic inflammations.However, low water solubility limits its therapeutic effi-cacy and novelnanoformulations are required to bypass its poor bioavailability to reach its therapeuticeffect. The purpose of the study was to investigate the role of the nanoformulation ofbiocompatible molecules; Squa-lene (S) and Tween 80 (T8) Micellar/NiosomalVesicles (ST8MNV) prepared, by thin-film hydration method and their potential as adrug delivery system for NPX. The percentage of encapsulation efficiency wascalculated to be 99.5 ± 0.2% for 5% of NPX weight in total ingredients ofmicellar/niosomal vesicles (w/w). The ST8MNV nanoformulation exhibited a slowerrate of NPX release from the drug encapsulated over seven days, suggesting a stablecomplex of NPX. Finally, cell toxicity assay demonstrated that the half-maximalinhibitory concentrations (IC50) of NPX were drastically reduced by ST8MNVnanoformulation in MCF-7, A549, HeLa, and MDA-MB-231 cancer cell lines. Ourdata show this micellar/niosomal naproxen nanoformulation is a great candidate forthe future in vitro and in vivo studies for potential clinical anti-inflammatory andanticancer applications.
cancer cells
Physicochemical characterization
cytotoxicity evaluation
, Author
shirvani, shahin
, Thesis advisor
, Consulting advisor
eshaghi, hamid
eshaghi, hamid
Tehran University of Medical Sciences, Medicine school
ایران
20230425
12642T
p
TL
276903
a
Y
