عنوان

Next generation sequencing technologies and challenges in sequence assembly

9781493907144 )pbk : acid-free paper(

Next generation sequencing technologies and challenges in sequence assembly

Sara El-Metwally, Osama M. Ouda, Mohamed Helmy

xii, 118 pages : illustrations

SpringerBriefs in Systems Biology,2193-4746

Series: SpringerBriefs in systems biology.2193-4746

Basics of molecular biology for next-generation sequencing -- Algorithms and data structures in next-generation sequencing -- First- and next-generations sequencing methods -- Next-generation sequencing platforms -- Challenges in the next-generation sequencing field -- New horizons in next-generation sequencing -- Novel next-generation sequencing applications -- Next-generation sequence assembly overview -- Approaches and challenges of next-generation sequence assembly stages -- Assessment of next-generation sequence assembly -- Next-generation sequence assemblers.

The introduction of Next Generation Sequencing )NGS( technologies resulted in a major transformation in the way scientists extract genetic information from biological systems, revealing limitless insight about the genome, transcriptome and epigenome of any species. However, with NGS, came its own challenges that require continuous development in the sequencing technologies and bioinformatics analysis of the resultant raw data and assembly of the full length genome and transcriptome. Such developments lead to outstanding improvements of the performance and coverage of sequencing and improved quality for the assembled sequences, nevertheless, challenges such as sequencing errors, expensive processing and memory usage for assembly and sequencer specific errors remains major challenges in the field. This book aims to provide brief overviews the NGS field with special focus on the challenges facing the NGS field, including information on different experimental platforms, assembly algorithms and software tools, assembly error correction approaches and the correlated challenges.--Source other than the Library of Congress.

Includes bibliographical references.

Sequence alignment )Bioinformatics(

Nucleotide sequence

Sequence Analysis, DNA

Base Sequence

Sequence Alignment

Nucleotide sequence.^afast--)OCoLC(fst01041106

Sequence alignment )Bioinformatics(^afast--)OCoLC(fst01747147

El-Metwally, Sara author

Title

Ouda, Osama M.

Helmy, Mohamed

English Book