عنوان

Protein surface recognition : approaches for the inhibition of protein-protein interactions for drug discovery

85769

Protein surface recognition : approaches for the inhibition of protein-protein interactions for drug discovery

Chichester, West Sussex

John Wiley & Sons

2011

xvi, 321 p. : ill. )some col.(

Includes bibliographical references and index

editors, Ernest Giralt, Mark Peczuh, Xavier Salvatella

The discovery and characterization of protein-protein interactions / C. Bertoncini, A. Higueruelo, and Xavi Salvatella -- Biophysics of protein-protein interactions / Irene Luque -- On the logic of natural product binding in protein-protein interactivity / James J. La Clair -- Interface peptide inhibitors of PPIs / Mark W. Peczuh, and Richard T. Desmond -- Inhibition of protein-protein interactions by peptide mimics / Jorge Becerril ... ]et al.[ -- Discovery of inhibitors of protein-protein interactions by screening chemical libraries / Carlos Garcia-Echeverria -- High-throughput methods of chemical synthesis applied to the preparation of inhibitors of protein-protein interactions / Annaliese K. Franz, Jared T. Shaw, and Yuchen Tang -- In silico screening / F.J. Luque, and Xavier Barril -- In vitro and in vivo screening : screening by nuclear magnetic resonance / Ernest Giralt -- In vitro and in vivo screening : methods of high throughput screening / Wenjiao Song and Qing Lin -- Case study : inhibitors of the MDM2-p35 protein-protein interaction / Sanjeev Shangary, Denzil Bernard, and Shaomeng Wang -- Case study : the discovery of potent LFA-1 antagonists / Tom Gadek

Design ، Drugs

، Protein-protein interactions

Inhibitors ، Proteins

، High throughput screening )Drug development(

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