Handbook of drug monitoring methods: therapeutics and drugs of abuse
Totowa, N.J.
Springer
2008
x, 445 p.: ill.; 26 cm.
Introduction to therapeutic drug monitoring -- Monitoring free drug concentation -- Analytical techniques for measuring concentrations of therapeutic drugs in biological fluids -- The pre-analytical phase of drug testing: from specimen collection to analysis -- Effect of hemolysis, high bilirubin, lipemia, paraproteins, and system factors on therapeutic drug monitoring -- Digoxin: so many interferences and how to eliminate them -- Interferences with measurement of anticonvulsants -- Pitfalls in measuring antidepressant drugs -- Immunosuppressive drugs: pharmacokinetics, preanalytic variables, and analytical considerations -- Therapeutic drug monitoring in human immunodeficiency virus/acquired immunodeficiency syndrome -- Pharmacogenetics and personalized medicine: issues and methodology -- Interference of heterophilic and other antibodies in measurement of therapeutic drugs by immunoassays -- Drug-herb and drug-food interactions: impact on therapeutic drug monitoring -- Toxic element testing with clinical specimens -- Alcohol testing -- Introduction to drugs of abuse testing -- Urinary adulterants and drugs of abuse testing -- Hair, oral fluid, sweat, and meconium testing for drugs of abuse: advantages and pitfalls -- Abused and designer drugs and how they escape detection -- Interpretation of amphetamines screening and confirmation testing -- Clinical false-positive drug test results -- Providing expert witness for alcohol and positive drugs of abuse test results