Experiencing depression / Lewis Wolpert -- Depression in the medically ill / Monica Kelly Cowles, Carmine Pariante & Charles B Nemeroff - Explaining depression: neuroscience is not enough, evolution is essential / Randolph M Nesse -- Evolutionary genetics of affective disorders / Bernard J Crespi -- Genetic factors in stress and major depression / Stephan Claes, Elisabeth B Binder & Charles B Nemeroff -- Bipolar disorder and unipolar depression: what is the genetic relationship? / Daniel J Smith, Michael J Owen & Nick Craddock -- The significance of dysregulated basal glucocorticoid pulsatility in affective disorders / Becky Conway-Campbell, C C Wiles & Stafford Lightman -- Early life programming of affective function / Caitlin S Wyrwoll, Megan C Holmes & Jonathan R Seckl -- Modeling depression by GR mutant animals? / Sabine Chourbaji & Peter Gass -- Cytokines and depression: experimental evidence and intermediate mechanisms / Robert Dantzer, Jason C O'Connor, Nathalie Castanon, Jacques Lestage & Keith W Kelley -- Do depression, stress, sleep disruption and inflammation alter hippocampal apoptosis and neurogenesis? / Paul Lucassen, Peter Meerlo, A S Naylor, A M van Dam, A G Dayer, B Czeh & C A Oomen -- The role of the medial prefrontal cortex in mediating resistance and vulnerability to the impact of adverse events / Steven F Maier, Jose Amat, Michael V Baratta, Sondra T Bland, John C Christianson, Brittany Thompson, Robert R Rozeske & Linda R Watkins -- Is it all monoamines? / Philip J Cowen & C J Harmer -- The role of affective processing in vulnerability to and resilience against depression / Nicole Geschwind, Jim van Os, Frenk Peeters & Marieke Wichers -- PTSD and HPA axis: same hormones, different disorders / Elizabeth Young -- Neuroendocrine and immune cross talk in major depression / Timothy G Dinan & Peter Fitzgerald -- Neuropsychiatric effects of IFN-alpha: relevance to depression / Andrew H Miller, Thaddeus W W Pace & Charles I Raison -- Depression and coronary heart disease / Andrew Steptoe -- Does depression induce pain and fatigue? / Tony Cleare -- Explaining the association between depression and mortality: a life course epidemiology approach / Matthew Hotopf & Max Henderson -- Depression: unipolar or bipolar, what's the difference (and what does it matter anyway)? / Allan H Young -- Can neuroimaging help distinguish bipolar depression from major depressive disorder? / Matthew T Keener & Mary L Phillips -- Pharmacogenetics of antidepressant response / Bhanu Gupta, Robert Keers, Rudolf Uher, Peter McGuffin & Katherine J Aitchison -- Can the EEG be used to predict antidepressant response? / R Hamish McAllister-Williams & Grzegorz Wisniewski -- Can we use magnetic/electric fields to help in treatment resistant depression? / Thomas E Schlaepfer & Bettina Bewernick -- Antiglucocorticoids in the treatment of affective disorders: from pre-clinical to clinical studies / Sarah E Gartside, K S Reid & I Nicol Ferrier -- How can we use current knowledge to improve antidepressant treatments? /David Nutt & Christoher A Lowry.